[HTML][HTML] CD2-associated protein (CD2AP) expression in podocytes rescues lethality of CD2AP deficiency
JA Grunkemeyer, C Kwoh, TB Huber… - Journal of Biological …, 2005 - ASBMB
Mice born without CD2-associated protein (CD2AP) develop renal failure and nephrotic
syndrome about 4 weeks after birth and die around 6 weeks of age. Although CD2AP is
widely expressed, the severity of the renal failure precludes a clear determination of the role
of CD2AP in other tissues. Here we generated transgenic mice expressing CD2AP using a
podocyte-specific promoter. Podocyte-specific expression of CD2AP prevented the
development of proteinuria, demonstrating that the renal failure is solely due to loss of …
syndrome about 4 weeks after birth and die around 6 weeks of age. Although CD2AP is
widely expressed, the severity of the renal failure precludes a clear determination of the role
of CD2AP in other tissues. Here we generated transgenic mice expressing CD2AP using a
podocyte-specific promoter. Podocyte-specific expression of CD2AP prevented the
development of proteinuria, demonstrating that the renal failure is solely due to loss of …