[HTML][HTML] A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis
H Mai, WS May, F Gao, Z Jin, X Deng - Journal of Biological Chemistry, 2003 - ASBMB
Nicotine is not only a major component in tobacco but is also a survival agonist that inhibits
apoptosis induced by diverse stimuli including chemotherapeutic drugs. However, the
intracellular mechanism (s) involved in nicotine suppression of apoptosis is unclear. Bcl2 is
a potent antiapoptotic protein and tumor promotor that is expressed in both small cell lung
cancer (SCLC) and non-small cell lung cancer (NSCLC) cells. It is possible that nicotine may
regulate Bcl2 to stimulate cell survival. Here we report that nicotine can induce Bcl2 …
apoptosis induced by diverse stimuli including chemotherapeutic drugs. However, the
intracellular mechanism (s) involved in nicotine suppression of apoptosis is unclear. Bcl2 is
a potent antiapoptotic protein and tumor promotor that is expressed in both small cell lung
cancer (SCLC) and non-small cell lung cancer (NSCLC) cells. It is possible that nicotine may
regulate Bcl2 to stimulate cell survival. Here we report that nicotine can induce Bcl2 …