[HTML][HTML] The stability of the G protein-coupled receptor-β-arrestin interaction determines the mechanism and functional consequence of ERK activation
A Tohgo, EW Choy, D Gesty-Palmer, KL Pierce… - Journal of Biological …, 2003 - ASBMB
By binding to agonist-activated G protein-coupled receptors (GPCRs), β-arrestins mediate
homologous receptor desensitization and endocytosis via clathrin-coated pits. Recent data
suggest that β-arrestins also contribute to GPCR signaling by acting as scaffolds for
components of the ERK mitogen-activated protein kinase cascade. Because of these dual
functions, we hypothesized that the stability of the receptor-β-arrestin interaction might affect
the mechanism and functional consequences of GPCR-stimulated ERK activation. In …
homologous receptor desensitization and endocytosis via clathrin-coated pits. Recent data
suggest that β-arrestins also contribute to GPCR signaling by acting as scaffolds for
components of the ERK mitogen-activated protein kinase cascade. Because of these dual
functions, we hypothesized that the stability of the receptor-β-arrestin interaction might affect
the mechanism and functional consequences of GPCR-stimulated ERK activation. In …