The choice between alternative IIIb and IIIc exons of the FGFR-3 gene is not strictly tissue-specific
E Scotet, E Houssaint - Biochimica et Biophysica Acta (BBA)-Gene …, 1995 - Elsevier
An essential feature of fibroblast growth factor receptors (FGFR) is the existence of multiple
possibilities for alternative splicing. One of these concerns sequences of the mRNA coding
for the C-terminal half of Ig domain 3 which correpponds to a part of the ligand-binding site.
Two alternative exons, IIIb and IIIc, encode the C-terminal half of Ig domain 3. We show here
that the alternative splicing choice between IIIb and IIIc exons of the FGFR-3 is not strictly
tissue-specific: epithelial cells show exclusively IIIb transcripts while fibroblastic cells show a …
possibilities for alternative splicing. One of these concerns sequences of the mRNA coding
for the C-terminal half of Ig domain 3 which correpponds to a part of the ligand-binding site.
Two alternative exons, IIIb and IIIc, encode the C-terminal half of Ig domain 3. We show here
that the alternative splicing choice between IIIb and IIIc exons of the FGFR-3 is not strictly
tissue-specific: epithelial cells show exclusively IIIb transcripts while fibroblastic cells show a …