T cells from the small intestinal Mucosa of a DR4, DQ7/DR4. DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
CD is an immunologic disease of the small intestine which is precipitated by ingestion of
wheat gliadin. Most patients carry the HLA-DQ (α1∗ 0501, β1∗ 0201)(DQ2) heterodimer.
We recently reported that a prepoderance of gliadin-specific T cells from the small intestinal
mucosa of DQ2-positive CD patients were restricted by this DQ heterodimer. However, a
small percentage of CD patients do not carry this DQ heterodimer, and most of them instead
carry DQ (α1∗ 0301, β1∗ 0302)(DQ8). Here we report that a majority of gliadin-specific T …
wheat gliadin. Most patients carry the HLA-DQ (α1∗ 0501, β1∗ 0201)(DQ2) heterodimer.
We recently reported that a prepoderance of gliadin-specific T cells from the small intestinal
mucosa of DQ2-positive CD patients were restricted by this DQ heterodimer. However, a
small percentage of CD patients do not carry this DQ heterodimer, and most of them instead
carry DQ (α1∗ 0301, β1∗ 0302)(DQ8). Here we report that a majority of gliadin-specific T …