Ischemic-like condition releases norepinephrine and purines from different sources in superfused rat spleen strips

B Sperlágh, M Dóda, M Baranyi, G Haskó - Journal of neuroimmunology, 2000 - Elsevier
Transmitters and cotransmitters of the sympathetic nervous system are involved in the
regulation of a variety of immune cell functions. However, it is not entirely clear what stimuli
lead to the release of these molecules in immune organs. In this study, we investigated
whether local ischemia can cause the parallel release of norepinephrine and its
cotransmitter, ATP, in the spleen. Ischemic-like conditions, simulated by transient (15 min)
O2 and glucose deprivation, elicited a reversible increase in the release of both …