High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock
C Martin, M Leone, X Viviand, ML Ayem… - Critical care …, 2000 - journals.lww.com
Objective Sepsis and septic shock are a common cause of mortality in critically ill patients.
Many substances have been implicated in the pathophysiology of these syndromes. We
postulated that adenosine may be implicated in the sepsis-or septic shock-induced blood
pressure failure. Indeed, this nucleoside is a strong endogenous vasodilating agent
released by endothelial cells and myocytes under circumstances of metabolic stress, such
as during critical illness. Design
Many substances have been implicated in the pathophysiology of these syndromes. We
postulated that adenosine may be implicated in the sepsis-or septic shock-induced blood
pressure failure. Indeed, this nucleoside is a strong endogenous vasodilating agent
released by endothelial cells and myocytes under circumstances of metabolic stress, such
as during critical illness. Design