[HTML][HTML] A Xestospongin C-sensitive Ca2+ Store Is Required for cAMP-induced Ca2+ Influx and cAMP Oscillations inDictyostelium
R Schaloske, C Schlatterer, D Malchow - Journal of biological chemistry, 2000 - ASBMB
Xestospongin C (XeC) is known to bind to the inositol 1, 4, 5-trisphosphate (IP 3)-sensitive
store in mammalian cells and to inhibit IP 3-and thapsigargin-induced Ca 2+ release. In this
study we show that this is also true for Dictyostelium. In addition, XeC inhibited Ca 2+ uptake
into purified vesicle fractions and induced Ca 2+ release. This suggests that, in the case
ofDictyostelium, XeC opens rather than plugs the IP 3 receptor channel as was proposed for
mammalian cells (Gafni, J., Munsch, JA, Lam, TH, Catlin, MC, Costa, LG, Molinski, TF, and …
store in mammalian cells and to inhibit IP 3-and thapsigargin-induced Ca 2+ release. In this
study we show that this is also true for Dictyostelium. In addition, XeC inhibited Ca 2+ uptake
into purified vesicle fractions and induced Ca 2+ release. This suggests that, in the case
ofDictyostelium, XeC opens rather than plugs the IP 3 receptor channel as was proposed for
mammalian cells (Gafni, J., Munsch, JA, Lam, TH, Catlin, MC, Costa, LG, Molinski, TF, and …