[HTML][HTML] Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin
H Wang, S Faucette, R Moore, T Sueyoshi… - Journal of Biological …, 2004 - ASBMB
Compared with its rodent orthologs, little is known about the chemical specificity of human
constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression.
Phenytoin (PHY), a widely used antiepileptic drug, is a potent inducer of CYP2B6 in primary
human hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in
cell-based transfection assays at the same concentrations associated with potent induction
of CYP2B6. Based on this observation, we hypothesized that PHY may be a selective …
constitutive androstane receptor (hCAR) and its regulation of hepatic enzyme expression.
Phenytoin (PHY), a widely used antiepileptic drug, is a potent inducer of CYP2B6 in primary
human hepatocytes, but does not activate human pregnane X receptor (PXR) significantly in
cell-based transfection assays at the same concentrations associated with potent induction
of CYP2B6. Based on this observation, we hypothesized that PHY may be a selective …