[HTML][HTML] Redundant cell death mechanisms as relics and backups
P Golstein, G Kroemer - Cell Death & Differentiation, 2005 - nature.com
Cell Death & Differentiation, 2005•nature.com
Here we review recent observations indicating the existence of redundant cell death
mechanisms. We speculate that this redundancy reflects a particular evolutionary history for
cellular demise. Autophagic or apoptotic elements might have been added to a primordial
death mechanism, initially improving cell dismantling and later acquiring the ability to act
themselves as death effectors. The resulting redundancy of cell death mechanisms has
pathophysiological implications.
mechanisms. We speculate that this redundancy reflects a particular evolutionary history for
cellular demise. Autophagic or apoptotic elements might have been added to a primordial
death mechanism, initially improving cell dismantling and later acquiring the ability to act
themselves as death effectors. The resulting redundancy of cell death mechanisms has
pathophysiological implications.
Abstract
Here we review recent observations indicating the existence of redundant cell death mechanisms. We speculate that this redundancy reflects a particular evolutionary history for cellular demise. Autophagic or apoptotic elements might have been added to a primordial death mechanism, initially improving cell dismantling and later acquiring the ability to act themselves as death effectors. The resulting redundancy of cell death mechanisms has pathophysiological implications.
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