[HTML][HTML] Fatty acid binding proteins stabilize leukotriene A4: competition with arachidonic acid but not other lipoxygenase products
JSD Zimmer, DF Dyckes, DA Bernlohr… - Journal of lipid …, 2004 - ASBMB
Leukotriene A 4 (LTA 4) is a chemically reactive conjugated triene epoxide product derived
from 5-lipoxygenase oxygenation of arachidonic acid. At physiological pH, this reactive
compound has a half-life of less than 3 s at 37° C and∼ 40 s at 4° C. Regardless of this
aqueous instability, LTA 4 is an intermediate in the formation of biologically active
leukotrienes, which can be formed through either intracellular or transcellular biosynthesis.
Previously, epithelial fatty acid binding protein (E-FABP) present in RBL-1 cells was shown …
from 5-lipoxygenase oxygenation of arachidonic acid. At physiological pH, this reactive
compound has a half-life of less than 3 s at 37° C and∼ 40 s at 4° C. Regardless of this
aqueous instability, LTA 4 is an intermediate in the formation of biologically active
leukotrienes, which can be formed through either intracellular or transcellular biosynthesis.
Previously, epithelial fatty acid binding protein (E-FABP) present in RBL-1 cells was shown …