Sequential development of interleukin 2–dependent effector and regulatory T cells in response to endogenous systemic antigen

B Knoechel, J Lohr, E Kahn, JA Bluestone… - The Journal of …, 2005 - rupress.org
B Knoechel, J Lohr, E Kahn, JA Bluestone, AK Abbas
The Journal of experimental medicine, 2005rupress.org
Transfer of naive antigen-specific CD4+ T cells into lymphopenic mice that express an
endogenous antigen as a systemic, secreted protein results in severe autoimmunity
resembling graft-versus-host disease. T cells that respond to this endogenous antigen
develop into effector cells that cause the disease. Recovery from this disease is associated
with the subsequent generation of FoxP3+ CD25+ regulatory cells in the periphery. Both
pathogenic effector cells and protective regulatory cells develop from the same antigen …
Transfer of naive antigen-specific CD4+ T cells into lymphopenic mice that express an endogenous antigen as a systemic, secreted protein results in severe autoimmunity resembling graft-versus-host disease. T cells that respond to this endogenous antigen develop into effector cells that cause the disease. Recovery from this disease is associated with the subsequent generation of FoxP3+CD25+ regulatory cells in the periphery. Both pathogenic effector cells and protective regulatory cells develop from the same antigen-specific T cell population after activation, and their generation may occur in parallel or sequentially. Interleukin (IL)-2 plays a dual role in this systemic T cell reaction. In the absence of IL-2, the acute disease is mild because of reduced T cell effector function, but a chronic and progressive disease develops late and is associated with a failure to generate FoxP3+ regulatory T (T reg) cells in the periphery. Thus, a peripheral T cell reaction to a systemic antigen goes through a phase of effector cell–mediated pathology followed by T reg cell–mediated recovery, and both require the growth factor IL-2.
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