Selective estrogen receptor modulators (SERMs): mechanisms of anticarcinogenesis and drug resistance
JS Lewis, VC Jordan - Mutation Research/Fundamental and Molecular …, 2005 - Elsevier
Despite the beneficial effects of estrogens in women's health, there is a plethora of evidence
that suggest an important role for these hormones, particularly 17β-estradiol (E2), in the
development and progression of breast cancer. Most estrogenic responses are mediated by
estrogen receptors (ERs), either ERα or ERβ, which are members of the nuclear receptor
superfamily of ligand-dependent transcription factors. Selective estrogen receptor
modulators (SERMs) are ER ligands that in some tissues (ie bone and cardiovascular …
that suggest an important role for these hormones, particularly 17β-estradiol (E2), in the
development and progression of breast cancer. Most estrogenic responses are mediated by
estrogen receptors (ERs), either ERα or ERβ, which are members of the nuclear receptor
superfamily of ligand-dependent transcription factors. Selective estrogen receptor
modulators (SERMs) are ER ligands that in some tissues (ie bone and cardiovascular …
