[HTML][HTML] Two independent nuclear localization signals are present in the DNA-binding high-mobility group domains of SRY and SOX9
P Südbeck, G Scherer - Journal of Biological Chemistry, 1997 - ASBMB
SRY and SOX9, members of the family of high-mobility group (HMG) domain transcription
factors, are both essential for testis formation during human embryonic development. The
HMG domain is a DNA-binding and DNA-bending motif comprising about 80 amino acid
residues. It has been shown that SRY and SOX9 are nuclear proteins. Using normal or
mutant SRY-β-galactosidase and SOX9-β-galactosidase fusion proteins in transfection
studies involving COS-7 cells, we have identified two nuclear localization signals (NLSs) …
factors, are both essential for testis formation during human embryonic development. The
HMG domain is a DNA-binding and DNA-bending motif comprising about 80 amino acid
residues. It has been shown that SRY and SOX9 are nuclear proteins. Using normal or
mutant SRY-β-galactosidase and SOX9-β-galactosidase fusion proteins in transfection
studies involving COS-7 cells, we have identified two nuclear localization signals (NLSs) …