Regulatory T cell-mediated transplantation tolerance
A Bharat, RC Fields, T Mohanakumar - Immunologic research, 2005 - Springer
A Bharat, RC Fields, T Mohanakumar
Immunologic research, 2005•SpringerThe existence of naturally occurring regulatory T cells in normal hosts and their pivotal role
in maintaining both auto-and allo-tolerance have direct implications on the therapy of
autoimmune disorders and for achieving immunosuppression-free allotransplantation.
Among the various forms of regulatory T cells described, CD4+ CD25+ T cells have
emerged as one of the most potent tolerogenic subsets. In this review, we discuss the
molecular basis of development and function of these regulatory T cells and their potential …
in maintaining both auto-and allo-tolerance have direct implications on the therapy of
autoimmune disorders and for achieving immunosuppression-free allotransplantation.
Among the various forms of regulatory T cells described, CD4+ CD25+ T cells have
emerged as one of the most potent tolerogenic subsets. In this review, we discuss the
molecular basis of development and function of these regulatory T cells and their potential …
Abstract
The existence of naturally occurring regulatory T cells in normal hosts and their pivotal role in maintaining both auto- and allo-tolerance have direct implications on the therapy of autoimmune disorders and for achieving immunosuppression-free allotransplantation. Among the various forms of regulatory T cells described, CD4+CD25+ T cells have emerged as one of the most potent tolerogenic subsets. In this review, we discuss the molecular basis of development and function of these regulatory T cells and their potential role in the context of chronic lung allograft rejection.
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