Rescue of a Drosophila NF1 Mutant Phenotype by Protein Kinase A
I The, GE Hannigan, GS Cowley, S Reginald, Y Zhong… - Science, 1997 - science.org
I The, GE Hannigan, GS Cowley, S Reginald, Y Zhong, JF Gusella, IK Hariharan, A Bernards
Science, 1997•science.orgThe neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell
proliferation by functioning as a Ras-specific guanosine triphosphatase–activating protein.
However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious
signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of
larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling
but was restored by expression of activated adenosine 3′, 5′-monophosphate …
proliferation by functioning as a Ras-specific guanosine triphosphatase–activating protein.
However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious
signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of
larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling
but was restored by expression of activated adenosine 3′, 5′-monophosphate …
The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase–activating protein. However,Drosophila homozygous for null mutations of anNF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated adenosine 3′,5′-monophosphate–dependent protein kinase (PKA). Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila.
AAAS