[HTML][HTML] Intrathecal B-cell clonal expansion, an early sign of humoral immunity, in the cerebrospinal fluid of patients with clinically isolated syndrome suggestive of …
Y Qin, P Duquette, Y Zhang, M Olek, RR Da… - Laboratory …, 2003 - Elsevier
The development of somatically mutated memory and plasma B cells is a consequence of T
cell-dependent antigen-challenged humoral immunity. To investigate the role of B cell-
mediated humoral immunity in the initiation and evolution of multiple sclerosis (MS), we
analyzed Ig variable heavy chain genes of intrathecal B cells derived from patients with a
first clinical manifestation suggestive of MS. Sequences of Ig variable regions showed that B
cells in the cerebrospinal fluid from most of these patients were clonally expanded and …
cell-dependent antigen-challenged humoral immunity. To investigate the role of B cell-
mediated humoral immunity in the initiation and evolution of multiple sclerosis (MS), we
analyzed Ig variable heavy chain genes of intrathecal B cells derived from patients with a
first clinical manifestation suggestive of MS. Sequences of Ig variable regions showed that B
cells in the cerebrospinal fluid from most of these patients were clonally expanded and …