[HTML][HTML] Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic …
R Zhang, Y Xu, N Ekman, Z Wu, J Wu, K Alitalo… - Journal of Biological …, 2003 - ASBMB
Tumor necrosis factor (TNF), via its receptor 2 (TNFR2), induces Etk (or Bmx) activation and
Etk-dependent endothelial cell (EC) migration and tube formation. Because TNF receptor 2
lacks an intrinsic kinase activity, we examined the kinase (s) mediating TNF-induced Etk
activation. TNF induces a coordinated phosphorylation of vascular endothelial growth factor
(VEGF) receptor 2 (VEGFR2) and Etk, which is blocked by VEGFR2-specific inhibitors. In
response to TNF, Etk and VEGFR2 form a complex resulting in a reciprocal activation …
Etk-dependent endothelial cell (EC) migration and tube formation. Because TNF receptor 2
lacks an intrinsic kinase activity, we examined the kinase (s) mediating TNF-induced Etk
activation. TNF induces a coordinated phosphorylation of vascular endothelial growth factor
(VEGF) receptor 2 (VEGFR2) and Etk, which is blocked by VEGFR2-specific inhibitors. In
response to TNF, Etk and VEGFR2 form a complex resulting in a reciprocal activation …