Immunosuppression after endotoxin shock: the result of multiple anti-inflammatory factors
WG Junger, DB Hoyt, FC Liu, WH Loomis… - Journal of Trauma …, 1996 - journals.lww.com
WG Junger, DB Hoyt, FC Liu, WH Loomis, R Coimbra
Journal of Trauma and Acute Care Surgery, 1996•journals.lww.comObjectives Endotoxin induced suppression of cellular immune function is thought to
contribute to septic complications in trauma patients. A rabbit model of endotoxemia was
used to determine the relative roles of the anti-inflammatory factors interleukin-4 (IL-4),
interleukin-10 (IL-10), transforming growth factor beta 1 (TGFbeta 1), and prostaglandin E
sub 2 (PGE 2) in addition to other factors, in inducing immunosuppression. Design T-cell
suppressive factors (TSF) in serum ultrafiltrates were separated and tested for the presence …
contribute to septic complications in trauma patients. A rabbit model of endotoxemia was
used to determine the relative roles of the anti-inflammatory factors interleukin-4 (IL-4),
interleukin-10 (IL-10), transforming growth factor beta 1 (TGFbeta 1), and prostaglandin E
sub 2 (PGE 2) in addition to other factors, in inducing immunosuppression. Design T-cell
suppressive factors (TSF) in serum ultrafiltrates were separated and tested for the presence …
Abstract
Objectives
Endotoxin induced suppression of cellular immune function is thought to contribute to septic complications in trauma patients. A rabbit model of endotoxemia was used to determine the relative roles of the anti-inflammatory factors interleukin-4 (IL-4), interleukin-10 (IL-10), transforming growth factor beta 1 (TGFbeta 1), and prostaglandin E sub 2 (PGE 2) in addition to other factors, in inducing immunosuppression.
Design
T-cell suppressive factors (TSF) in serum ultrafiltrates were separated and tested for the presence of the known suppressive factors PGE sub 2, IL-4, IL-10, and TGFbeta 1.
Lippincott Williams & Wilkins