[HTML][HTML] IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
H Wesche, X Gao, X Li, CJ Kirschning, GR Stark… - Journal of Biological …, 1999 - ASBMB
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal
transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of
other members of the Toll/IL-1 receptor family. We now report the identification and
characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed
IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic
origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a …
transducer for interleukin-1 (IL-1) and has later been implicated in signal transduction of
other members of the Toll/IL-1 receptor family. We now report the identification and
characterization of a novel IRAK-like molecule. In contrast to the ubiquitously expressed
IRAK and IRAK-2, this new IRAK-like molecule is found mainly in cells of monomyeloic
origin and is, therefore, designated IRAK-M. Although IRAK-M and IRAK-2 exhibit only a …