Three for T: molecular analysis of the low voltage-activated calcium channel family
E Perez-Reyes - Cellular and Molecular Life Sciences CMLS, 1999 - Springer
Cellular and Molecular Life Sciences CMLS, 1999•Springer
Despite the wealth of information on voltage-gated calcium channels, little is known about
low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to
selectively block T-type channels has generated much interest in their structure, physiology
and pharmacology. This review covers the cloning of a new family of calcium channels, their
putative structure, the electrophysiological evidence that demonstrated that these
complementary DNAs encoded low voltage-activated, T-type channels, the tissue …
low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to
selectively block T-type channels has generated much interest in their structure, physiology
and pharmacology. This review covers the cloning of a new family of calcium channels, their
putative structure, the electrophysiological evidence that demonstrated that these
complementary DNAs encoded low voltage-activated, T-type channels, the tissue …
Abstract
Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.
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