[HTML][HTML] Class I major histocompatibility complex anchor substitutions alter the conformation of T cell receptor contacts
AK Sharma, JJ Kuhns, S Yan, RH Friedline… - Journal of Biological …, 2001 - ASBMB
An immunogenic peptide (GP2) derived from HER-2/neu binds to HLA-A2. 1 very poorly.
Some altered-peptide ligands (APL) of GP2 have increased binding affinity and generate
improved cytotoxic T lymphocyte recognition of GP2-presenting tumor cells, but most do not.
Increases in binding affinity of single-substitution APL are not additive in double-substitution
APL. A common first assumption about peptide binding to class I major histocompatibility
complex is that each residue binds independently. In addition, immunologists interested in …
Some altered-peptide ligands (APL) of GP2 have increased binding affinity and generate
improved cytotoxic T lymphocyte recognition of GP2-presenting tumor cells, but most do not.
Increases in binding affinity of single-substitution APL are not additive in double-substitution
APL. A common first assumption about peptide binding to class I major histocompatibility
complex is that each residue binds independently. In addition, immunologists interested in …