Effect of glatiramer acetate (Copaxone) on CD4+ CD25high T regulatory cells and their IL-10 production in multiple sclerosis
P Putheti, M Soderstrom, H Link, YM Huang - Journal of neuroimmunology, 2003 - Elsevier
CD4+ CD25high T regulatory (Tr) cells, representing high IL-2 receptor α chain expressing
cells, have been shown to inhibit proliferation and cytokine secretion by CD4+ T cells that
are assumed to represent important effector cells in auto-aggressive immunity. Tr cells may
therefore be considered of importance in the pathogenesis of multiple sclerosis (MS).
Glatiramer acetate (GA; Copaxone) is approved as a disease-modulating agent that
ameliorates the course of MS. The goal of this study was to examine in vitro effects of GA on …
cells, have been shown to inhibit proliferation and cytokine secretion by CD4+ T cells that
are assumed to represent important effector cells in auto-aggressive immunity. Tr cells may
therefore be considered of importance in the pathogenesis of multiple sclerosis (MS).
Glatiramer acetate (GA; Copaxone) is approved as a disease-modulating agent that
ameliorates the course of MS. The goal of this study was to examine in vitro effects of GA on …