[HTML][HTML] Mechanism of human SIRT1 activation by resveratrol
The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many
cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell
cycle regulation, and life span extension. Resveratrol, a polyphenol found in wines and
thought to harbor major health benefits, was reported to be an activator of Sir2 enzymes in
vivo and in vitro. In addition, resveratrol was shown to increase life span in three model
organisms through a Sir2-dependent pathway. Here, we investigated the molecular basis for …
cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell
cycle regulation, and life span extension. Resveratrol, a polyphenol found in wines and
thought to harbor major health benefits, was reported to be an activator of Sir2 enzymes in
vivo and in vitro. In addition, resveratrol was shown to increase life span in three model
organisms through a Sir2-dependent pathway. Here, we investigated the molecular basis for …