RNA polymerase II as a control panel for multiple coactivator complexes
M Hampsey, D Reinberg - Current opinion in genetics & development, 1999 - Elsevier
M Hampsey, D Reinberg
Current opinion in genetics & development, 1999•Elsevier1999 marks the 30th anniversary of the reported discovery of σ factor and the bacterial RNA
polymerase holoenzyme. In 1994, an RNA polymerase II complex was discovered in yeast—
mammalian complexes were subsequently identified. Recent developments regarding the
composition and function of RNA polymerase II complexes suggest, however, that the
concept of the holoenzyme, as defined in bacteria, might not be relevant to eukaryotes.
polymerase holoenzyme. In 1994, an RNA polymerase II complex was discovered in yeast—
mammalian complexes were subsequently identified. Recent developments regarding the
composition and function of RNA polymerase II complexes suggest, however, that the
concept of the holoenzyme, as defined in bacteria, might not be relevant to eukaryotes.
1999 marks the 30th anniversary of the reported discovery of σ factor and the bacterial RNA polymerase holoenzyme. In 1994, an RNA polymerase II complex was discovered in yeast — mammalian complexes were subsequently identified. Recent developments regarding the composition and function of RNA polymerase II complexes suggest, however, that the concept of the holoenzyme, as defined in bacteria, might not be relevant to eukaryotes.
Elsevier