[HTML][HTML] FOXO forkhead transcription factors induce G2-M checkpoint in response to oxidative stress
Y Furukawa-Hibi, K Yoshida-Araki, T Ohta… - Journal of Biological …, 2002 - ASBMB
Members of the FOXO family of mammalian forkhead transcription factors, including AFX,
FKHRL1, and FKHR, are homologs of DAF-16, which regulates genes that contribute both to
longevity and to resistance to various stresses (including oxidative stress) in Caenorhabditis
elegans. We have generated mouse myoblastic C2C12 cell lines in which expression of a
constitutively active form of AFX (AFX-TM) is inducible by Cre-mediated recombination at
loxP sites. Here we show that forced expression of AFX-TM blocked cell cycle progression at …
FKHRL1, and FKHR, are homologs of DAF-16, which regulates genes that contribute both to
longevity and to resistance to various stresses (including oxidative stress) in Caenorhabditis
elegans. We have generated mouse myoblastic C2C12 cell lines in which expression of a
constitutively active form of AFX (AFX-TM) is inducible by Cre-mediated recombination at
loxP sites. Here we show that forced expression of AFX-TM blocked cell cycle progression at …