[HTML][HTML] Roles of spleen and liver in development of the murine hematopoietic system
FM Wolber, E Leonard, S Michael… - Experimental …, 2002 - Elsevier
OBJECTIVE: Hematopoietic stem cells (HSCs) and colony-forming progenitor cells (CFCs)
are believed to migrate from liver to bone marrow (BM) around the time of birth, where they
remain throughout the animal's life. Although in mice the spleen is also a hematopoietic
organ, neither the origin nor the contribution of spleen HSCs to hematopoietic homeostasis
has been assessed relative to that of BM HSCs. To investigate these issues we quantitated
CFC and HSC activity in the spleen, BM, peripheral blood, and liver of the mouse during …
are believed to migrate from liver to bone marrow (BM) around the time of birth, where they
remain throughout the animal's life. Although in mice the spleen is also a hematopoietic
organ, neither the origin nor the contribution of spleen HSCs to hematopoietic homeostasis
has been assessed relative to that of BM HSCs. To investigate these issues we quantitated
CFC and HSC activity in the spleen, BM, peripheral blood, and liver of the mouse during …