[HTML][HTML] Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex
DS Hansen, MA Siomos, L Buckingham, AA Scalzo… - Immunity, 2003 - cell.com
DS Hansen, MA Siomos, L Buckingham, AA Scalzo, L Schofield
Immunity, 2003•cell.comNKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they
rapidly produce high levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) and are therefore
postulated to influence TH 1/TH 2 immune responses. The precise role of the CD1/NKT cell
pathway in immune response to infection remains unclear. We show here that CD1d-
restricted NKT cells from distinct genetic backgrounds differentially influence TH 1/TH 2
polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei …
rapidly produce high levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) and are therefore
postulated to influence TH 1/TH 2 immune responses. The precise role of the CD1/NKT cell
pathway in immune response to infection remains unclear. We show here that CD1d-
restricted NKT cells from distinct genetic backgrounds differentially influence TH 1/TH 2
polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei …
Abstract
NKT cells are specialized cells coexpressing NK and T cell receptors. Upon activation they rapidly produce high levels of interferon-γ (IFN-γ) and interleukin-4 (IL-4) and are therefore postulated to influence TH1/TH2 immune responses. The precise role of the CD1/NKT cell pathway in immune response to infection remains unclear. We show here that CD1d-restricted NKT cells from distinct genetic backgrounds differentially influence TH1/TH2 polarization, proinflammatory cytokine levels, pathogenesis, and fatality in the P. berghei ANKA/rodent model of cerebral malaria. The functional properties of CD1d-restricted NKT cells vary according to expression of loci of the natural killer complex (NKC) located on mouse chromosome 6, which is shown here to be a significant genetic determinant of murine malarial fatalities.
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