[HTML][HTML] Enteropathogenic E. coli disrupts tight junction barrier function and structure in vivo
DE Shifflett, DR Clayburgh, A Koutsouris… - Laboratory …, 2005 - Elsevier
Enteropathogenic Escherichia coli (EPEC) infection disrupts tight junctions (TJs) and
perturbs intestinal barrier function in vitro. E. coli secreted protein F (EspF) is, in large part,
responsible for these physiological and morphological alterations. We recently reported that
the C57BL/6J mouse is a valid in vivo model of EPEC infection as EPEC colonizes the
intestinal epithelium and effaces microvilli. Our current aim was to examine the effects of
EPEC on TJ structure and barrier function of the mouse intestine and to determine the role of …
perturbs intestinal barrier function in vitro. E. coli secreted protein F (EspF) is, in large part,
responsible for these physiological and morphological alterations. We recently reported that
the C57BL/6J mouse is a valid in vivo model of EPEC infection as EPEC colonizes the
intestinal epithelium and effaces microvilli. Our current aim was to examine the effects of
EPEC on TJ structure and barrier function of the mouse intestine and to determine the role of …
