Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
SK Mazmanian, G Liu, H Ton-That, O Schneewind - Science, 1999 - science.org
SK Mazmanian, G Liu, H Ton-That, O Schneewind
Science, 1999•science.orgSurface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a
mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that
occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant
defective in the anchoring of surface proteins was isolated and shown to carry a mutation in
the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and
homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein …
mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that
occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant
defective in the anchoring of surface proteins was isolated and shown to carry a mutation in
the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and
homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein …
Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein specified bysrtA, sortase, may be a useful target for the development of new antimicrobial drugs.
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