Acute generalized exanthematous pustulosis, a clue to neutrophil-mediated inflammatory processes orchestrated by T cells
M Britschgi, WJ Pichler - Current opinion in allergy and clinical …, 2002 - journals.lww.com
M Britschgi, WJ Pichler
Current opinion in allergy and clinical immunology, 2002•journals.lww.comT cells are involved even in some neutrophil-rich inflammatory responses, and they may
orchestrate the immune reaction directly by high CXCL8 production or indirectly via
interleukin-17 production, which induces CXCL8 production in various cell types. AGEP
serves as a valuable model for characterizing T cells with a particular function-namely
production of CXCL8-leading to neutrophilic inflammation. It is tempting to speculate that
elucidation of this pathomechanism will help to improve our understanding of similar …
orchestrate the immune reaction directly by high CXCL8 production or indirectly via
interleukin-17 production, which induces CXCL8 production in various cell types. AGEP
serves as a valuable model for characterizing T cells with a particular function-namely
production of CXCL8-leading to neutrophilic inflammation. It is tempting to speculate that
elucidation of this pathomechanism will help to improve our understanding of similar …
Summary
T cells are involved even in some neutrophil-rich inflammatory responses, and they may orchestrate the immune reaction directly by high CXCL8 production or indirectly via interleukin-17 production, which induces CXCL8 production in various cell types. AGEP serves as a valuable model for characterizing T cells with a particular function-namely production of CXCL8-leading to neutrophilic inflammation. It is tempting to speculate that elucidation of this pathomechanism will help to improve our understanding of similar neutrophilic eruptions (eg pustular psoriasis) and may reveal new targets for pharmacotherapeutic interventions in such diseases.
Lippincott Williams & Wilkins