[HTML][HTML] Transcription cooperation by NFAT· C/EBP composite enhancer complex
TTC Yang, CW Chow - Journal of biological chemistry, 2003 - ASBMB
The nuclear factor of activated T cells (NFAT) group of transcription factors regulates gene
expression in immune and non-immune cells. NFAT-mediated gene transcription is
orchestrated, in part, by formation of a composite regulatory element. Here we demonstrate
that NFAT interacts with transcription factor CCAAT/enhancer-binding protein (C/EBP) to
form a composite enhancer complex, to potentiate expression of the peroxisome proliferator-
activated receptor-γ2 gene. Formation of a ternary NFAT· C/EBP· DNA complex is required …
expression in immune and non-immune cells. NFAT-mediated gene transcription is
orchestrated, in part, by formation of a composite regulatory element. Here we demonstrate
that NFAT interacts with transcription factor CCAAT/enhancer-binding protein (C/EBP) to
form a composite enhancer complex, to potentiate expression of the peroxisome proliferator-
activated receptor-γ2 gene. Formation of a ternary NFAT· C/EBP· DNA complex is required …