[HTML][HTML] TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
M DeFelice, D Silberschmidt, R DiLauro, Y Xu… - Journal of Biological …, 2003 - ASBMB
Thyroid transcription factor-1 (TTF-1) is a 43-kDa, phosphorylated member of the Nkx2
family of homeodomain-containing proteins expressed selectively in lung, thyroid, and the
central nervous system. To assess the role of TTF-1 and its phosphorylation during lung
morphogenesis, mice bearing a mutant allele, in which seven serine phosphorylation sites
were mutated, Titf1 PM/PM, were generated by homologous recombination. Although
heterozygous Titf1 PM/+ mice were unaffected, homozygous Titf1 PM/PM mice died …
family of homeodomain-containing proteins expressed selectively in lung, thyroid, and the
central nervous system. To assess the role of TTF-1 and its phosphorylation during lung
morphogenesis, mice bearing a mutant allele, in which seven serine phosphorylation sites
were mutated, Titf1 PM/PM, were generated by homologous recombination. Although
heterozygous Titf1 PM/+ mice were unaffected, homozygous Titf1 PM/PM mice died …