[HTML][HTML] Mouse LYVE-1 is an endocytic receptor for hyaluronan in lymphatic endothelium
R Prevo, S Banerji, DJP Ferguson, S Clasper… - Journal of Biological …, 2001 - ASBMB
The glycosaminoglycan hyaluronan is a key substrate for cell migration in tissues during
inflammation, wound healing, and neoplasia. Unlike other matrix components, hyaluronan
(HA) is turned over rapidly, yet most degradation occurs not locally but within distant lymph
nodes, through mechanisms that are not yet understood. While it is not clear which receptors
are involved in binding and uptake of hyaluronan within the lymphatics, one likely candidate
is the lymphatic endothelial hyaluronan receptor LYVE-1 recently described in our …
inflammation, wound healing, and neoplasia. Unlike other matrix components, hyaluronan
(HA) is turned over rapidly, yet most degradation occurs not locally but within distant lymph
nodes, through mechanisms that are not yet understood. While it is not clear which receptors
are involved in binding and uptake of hyaluronan within the lymphatics, one likely candidate
is the lymphatic endothelial hyaluronan receptor LYVE-1 recently described in our …