[HTML][HTML] Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile
Y Ji, N Wang, R Ramakrishnan, E Sehayek… - Journal of Biological …, 1999 - ASBMB
The clearance of free cholesterol from plasma lipoproteins by tissues is of major quantitative
importance, but it is not known whether this is passive or receptor-mediated. Based on our
finding that scavenger receptor BI (SR-BI) promotes free cholesterol (FC) exchange between
high density lipoprotein (HDL) and cells, we tested whether SR-BI would effect FC
movement in vivo using [14 C] FC-and [3 H] cholesteryl ester (CE)-labeled HDL in mice with
increased (SR-BI transgenic (Tg)) or decreased (SR-BI attenuated (att)) hepatic SR-BI …
importance, but it is not known whether this is passive or receptor-mediated. Based on our
finding that scavenger receptor BI (SR-BI) promotes free cholesterol (FC) exchange between
high density lipoprotein (HDL) and cells, we tested whether SR-BI would effect FC
movement in vivo using [14 C] FC-and [3 H] cholesteryl ester (CE)-labeled HDL in mice with
increased (SR-BI transgenic (Tg)) or decreased (SR-BI attenuated (att)) hepatic SR-BI …