[HTML][HTML] Lower plasma levels and accelerated clearance of high density lipoprotein (HDL) and non-HDL cholesterol in scavenger receptor class B type I transgenic …
Y Ueda, L Royer, E Gong, J Zhang, PN Cooper… - Journal of Biological …, 1999 - ASBMB
Recent studies have indicated that the scavenger receptor class B type I (SR-BI) may play
an important role in the uptake of high density lipoprotein (HDL) cholesteryl ester in liver and
steroidogenic tissues. To investigate the in vivo effects of liver-specific SR-BI overexpression
on lipid metabolism, we created several lines of SR-BI transgenic mice with an SR-BI
genomic construct where the SR-BI promoter region had been replaced by the
apolipoprotein (apo) AI promoter. The effect of constitutively increased SR-BI expression on …
an important role in the uptake of high density lipoprotein (HDL) cholesteryl ester in liver and
steroidogenic tissues. To investigate the in vivo effects of liver-specific SR-BI overexpression
on lipid metabolism, we created several lines of SR-BI transgenic mice with an SR-BI
genomic construct where the SR-BI promoter region had been replaced by the
apolipoprotein (apo) AI promoter. The effect of constitutively increased SR-BI expression on …