[HTML][HTML] Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-α and interleukin-6: model of NF-κB-and map kinase-dependent …
Y Li, RF Schwabe, T DeVries-Seimon, PM Yao… - Journal of Biological …, 2005 - ASBMB
Two key features of atherosclerotic plaques that precipitate acute atherothrombotic vascular
occlusion (" vulnerable plaques") are abundant inflammatory mediators and macrophages
with excess unesterified, or" free," cholesterol (FC). Herein we show that FC accumulation in
macrophages leads to the induction and secretion of two inflammatory cytokines, tumor
necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The increases in TNF-α and IL-6 mRNA
and protein were mediated by FC-induced activation of the IκB kinase/NF-κB pathway as …
occlusion (" vulnerable plaques") are abundant inflammatory mediators and macrophages
with excess unesterified, or" free," cholesterol (FC). Herein we show that FC accumulation in
macrophages leads to the induction and secretion of two inflammatory cytokines, tumor
necrosis factor-α (TNF-α) and interleukin-6 (IL-6). The increases in TNF-α and IL-6 mRNA
and protein were mediated by FC-induced activation of the IκB kinase/NF-κB pathway as …