[HTML][HTML] Serum amyloid A binding to CLA-1 (CD36 and LIMPII analogous-1) mediates serum amyloid A protein-induced activation of ERK1/2 and p38 mitogen …
IN Baranova, TG Vishnyakova, AV Bocharov… - Journal of Biological …, 2005 - ASBMB
Serum amyloid A protein (SAA) is an acute-phase reactant, known to mediate pro-
inflammatory cellular responses. This study reports that CLA-1 (CD36 and LIMPII Analogous-
1; human orthologue of the Scavenger Receptor Class B Type I (SR-BI)) mediates SAA
uptake and downstream SAA signaling. Flow cytometry experiments revealed more than a 5-
fold increase of Alexa-488 SAA uptake in HeLa cells stably transfected with CLA-1. Alexa
488-HDL uptake directly correlated with SAA uptake when determined in several CLA-1 …
inflammatory cellular responses. This study reports that CLA-1 (CD36 and LIMPII Analogous-
1; human orthologue of the Scavenger Receptor Class B Type I (SR-BI)) mediates SAA
uptake and downstream SAA signaling. Flow cytometry experiments revealed more than a 5-
fold increase of Alexa-488 SAA uptake in HeLa cells stably transfected with CLA-1. Alexa
488-HDL uptake directly correlated with SAA uptake when determined in several CLA-1 …