[HTML][HTML] Decreased atherosclerosis in heterozygous low density lipoprotein receptor-deficient mice expressing the scavenger receptor BI transgene
T Arai, N Wang, M Bezouevski, C Welch… - Journal of Biological …, 1999 - ASBMB
Scavenger receptor type B class I (SR-BI), initially identified as a receptor that recognizes
low density lipoprotein (LDL), was recently shown to mediate the selective uptake of high
density lipoprotein (HDL) cholesteryl esters in liver and steroidogenic tissues. To evaluate
effects on atherosclerosis, transgenic mice with liver-specific overexpression of SR-BI (SR-BI
Tg mice) have been crossed onto LDL receptor-deficient backgrounds. To induce
atherosclerosis in a setting of moderate hypercholesterolemia, heterozygous LDL receptor …
low density lipoprotein (LDL), was recently shown to mediate the selective uptake of high
density lipoprotein (HDL) cholesteryl esters in liver and steroidogenic tissues. To evaluate
effects on atherosclerosis, transgenic mice with liver-specific overexpression of SR-BI (SR-BI
Tg mice) have been crossed onto LDL receptor-deficient backgrounds. To induce
atherosclerosis in a setting of moderate hypercholesterolemia, heterozygous LDL receptor …