[HTML][HTML] RhoG signals in parallel with Rac1 and Cdc42
K Wennerberg, SM Ellerbroek, RY Liu… - Journal of Biological …, 2002 - ASBMB
RhoG is a member of the Rho family of small GTPases and shares high sequence identity
with Rac1 and Cdc42. Previous studies suggested that RhoG mediates its effects through
activation of Rac1 and Cdc42. To further understand the mechanism of RhoG signaling, we
studied its potential activation pathways, downstream signaling properties, and functional
relationship to Rac1 and Cdc42 in vivo. First, we determined that RhoG was regulated by
guanine nucleotide exchange factors that also activate Rac and/or Cdc42. Vav2 (which …
with Rac1 and Cdc42. Previous studies suggested that RhoG mediates its effects through
activation of Rac1 and Cdc42. To further understand the mechanism of RhoG signaling, we
studied its potential activation pathways, downstream signaling properties, and functional
relationship to Rac1 and Cdc42 in vivo. First, we determined that RhoG was regulated by
guanine nucleotide exchange factors that also activate Rac and/or Cdc42. Vav2 (which …