TGF-ßs and their roles in the regulation of neuron survival

K Unsicker, K Krieglstein - … and Cellular Biology of Neuroprotection in the …, 2002 - Springer
K Unsicker, K Krieglstein
Molecular and Cellular Biology of Neuroprotection in the CNS, 2002Springer
Transforming growth factor-ßs (TGF-ßs) are a still growing superfamily of cytokines with
widespread distribution and diverse biological functions. They fall into several subfamilies
including the TGF-ßs 1, 2, and 3, the bone morphogenetic proteins (BMPs), the
growth/differentiation factors (GDFs), activins and inhibins, and the members of the glial cell
line-derived neurotrophic factor family. Following a brief description of their general roles
and signaling in development, maintenance of homeostasis, and disease, we shall focus on …
Abstract
Transforming growth factor-ßs (TGF-ßs) are a still growing superfamily of cytokines with widespread distribution and diverse biological functions. They fall into several subfamilies including the TGF-ßs 1, 2, and 3, the bone morphogenetic proteins (BMPs), the growth/differentiation factors (GDFs), activins and inhibins, and the members of the glial cell line-derived neurotrophic factor family. Following a brief description of their general roles and signaling in development, maintenance of homeostasis, and disease, we shall focus on their distribution in the CNS and their involvement in regulating neuron survival and death.
Springer