Myasthenia gravis is an autoimmune disease caused, in most cases, by antibodies attaching
to the acetylcholine receptor. Some myasthenia gravis patients have antibodies that bind in
a cross-striational pattern to skeletal and heart muscle tissue sections (striational
antibodies). These antibodies react with epitopes on the muscle proteins titin and ryanodine
receptor, are found mainly in sera of patients with thymoma and late-onset myasthenia
gravis, and may correlate with myasthenia gravis severity. Their presence may predict an …