Cytokine-modulated regulation of helper T cell populations
A Yates, C Bergmann, JL Van Hemmen, J Stark… - Journal of theoretical …, 2000 - Elsevier
Helper T (Th) cells are a crucial component of the adaptive immune system and are of
fundamental importance in orchestrating the appropriate response to pathogenic challenge.
They fall into two broad categories defined by the cytokines each produces. Th1 cells
produce interferon-γ and are required for effective immunity to intracellular bacteria, viruses
and protozoa whereas Th2 produce IL-4 and are required for optimal antibody production to
T-dependent antigens. A great deal of experimental data on the regulation of Th1 and Th2 …
fundamental importance in orchestrating the appropriate response to pathogenic challenge.
They fall into two broad categories defined by the cytokines each produces. Th1 cells
produce interferon-γ and are required for effective immunity to intracellular bacteria, viruses
and protozoa whereas Th2 produce IL-4 and are required for optimal antibody production to
T-dependent antigens. A great deal of experimental data on the regulation of Th1 and Th2 …