Immunomodulation by a dual altered peptide ligand of autoreactive responses to the acetylcholine receptor of peripheral blood lymphocytes of patients with …
M Dayan, Z Sthoeger, A Neiman, J Abarbanel… - Human immunology, 2004 - Elsevier
Myasthenia gravis (MG) is a T cell–dependent, antibody-mediated autoimmune disease. A
dual altered peptide ligand (APL) that is composed of the tandemly arranged two single
amino acid analogs of two myasthenogenic peptides was demonstrated to downregulate in
vitro and in vivo murine MG associated autoreactive responses. Furthermore, treatment with
the dual APL ameliorated the clinical manifestations of an established experimental
autoimmune MG in mice. This study was undertaken in order to investigate the ability of the …
dual altered peptide ligand (APL) that is composed of the tandemly arranged two single
amino acid analogs of two myasthenogenic peptides was demonstrated to downregulate in
vitro and in vivo murine MG associated autoreactive responses. Furthermore, treatment with
the dual APL ameliorated the clinical manifestations of an established experimental
autoimmune MG in mice. This study was undertaken in order to investigate the ability of the …