Subcutaneous administration of T-epitope sequences of the acetylcholine receptor prevents experimental myasthenia gravis
PI Karachunski, NS Ostlie, DK Okita, R Garman… - Journal of …, 1999 - Elsevier
Immunization with acetylcholine receptor (AChR) causes experimental myasthenia gravis
(EMG). The sc administration to C57Bl/6 mice of synthetic AChR CD4+ epitopes, before and
during AChR immunization, reduced the epitope-specific CD4+ responses and the anti-
AChR Ab synthesis, and prevented EMG. The sc administration of solubilized AChR had
effects similar to those of peptide treatment. Sham-tolerized mice had only Th1 anti-AChR
cells, whereas peptide-treated mice had also Th2 cells, and Th2-induced anti-peptide Ab …
(EMG). The sc administration to C57Bl/6 mice of synthetic AChR CD4+ epitopes, before and
during AChR immunization, reduced the epitope-specific CD4+ responses and the anti-
AChR Ab synthesis, and prevented EMG. The sc administration of solubilized AChR had
effects similar to those of peptide treatment. Sham-tolerized mice had only Th1 anti-AChR
cells, whereas peptide-treated mice had also Th2 cells, and Th2-induced anti-peptide Ab …