The'embryonic'gamma subunit of the nicotinic acetylcholine receptor is expressed in adult extraocular muscle
RM Horton, AA Manfredi, BM Conti-Tronconi - Neurology, 1993 - AAN Enterprises
RM Horton, AA Manfredi, BM Conti-Tronconi
Neurology, 1993•AAN EnterprisesWe have PCR-amplified cDNA sequence of the “embryonic” μM subunit of muscle
acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and
sequenced this product and used it to probe Northern blots. We detected the μM subunit in
EOM mRNA, but not in control skeletal muscle. The presence of y sub-unit in EOMs may
explain their preferential involvement in myasthenia gravis, where an autoimmune response
to the y subunit is generally present.
acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and
sequenced this product and used it to probe Northern blots. We detected the μM subunit in
EOM mRNA, but not in control skeletal muscle. The presence of y sub-unit in EOMs may
explain their preferential involvement in myasthenia gravis, where an autoimmune response
to the y subunit is generally present.
We have PCR-amplified cDNA sequence of the “embryonic” μM subunit of muscle acetylcholine receptor (AChR) from adult bovine extraocular muscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the μM subunit in EOM mRNA, but not in control skeletal muscle. The presence of y sub-unit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the y subunit is generally present.
American Academy of Neurology