Effects of antiviral therapy on the cellular immune response in acute hepatitis C
F Rahman, T Heller, Y Sobao, E Mizukoshi… - Hepatology, 2004 - journals.lww.com
Spontaneous recovery occurs in a minority of patients with acute hepatitis C but is
associated with vigorous and long-lasting cellular immune responses. Treatment-induced
recovery can be achieved in the majority of patients who are treated in the acute phase, but
the kinetics and mechanisms of viral clearance and immune responsiveness are not known.
Both direct antiviral effects and indirect immune-mediated effects, such as immune
modulation of Th2 to Th1 responses and prevention of exhaustion of cellular responses by …
associated with vigorous and long-lasting cellular immune responses. Treatment-induced
recovery can be achieved in the majority of patients who are treated in the acute phase, but
the kinetics and mechanisms of viral clearance and immune responsiveness are not known.
Both direct antiviral effects and indirect immune-mediated effects, such as immune
modulation of Th2 to Th1 responses and prevention of exhaustion of cellular responses by …