[HTML][HTML] Doubling expression of the low density lipoprotein receptor by truncation of the 3′-untranslated region sequence ameliorates type iii hyperlipoproteinemia in …
C Knouff, S Malloy, J Wilder, MK Altenburg… - Journal of Biological …, 2001 - ASBMB
The primary receptor mediating clearance of apolipoprotein (apo) E-and apoB100-
containing lipoproteins from the circulation is the low density lipoprotein (LDL) receptor.
Reduced expression of the LDLR is believed to be a precipitating factor in the pathogenesis
of type III hyperlipoproteinemia (HLP) in some humans homozygous for the apoE2 allele
(APOE* 2). To test the effect of genetic changes in LDL receptor expression on the
pathogenesis of type III HLP, we have generated a variant allele at the endogenous mouse …
containing lipoproteins from the circulation is the low density lipoprotein (LDL) receptor.
Reduced expression of the LDLR is believed to be a precipitating factor in the pathogenesis
of type III hyperlipoproteinemia (HLP) in some humans homozygous for the apoE2 allele
(APOE* 2). To test the effect of genetic changes in LDL receptor expression on the
pathogenesis of type III HLP, we have generated a variant allele at the endogenous mouse …