[HTML][HTML] Toll-like receptors as potential therapeutic targets for multiple diseases

C Zuany-Amorim, J Hastewell, C Walker - Nature Reviews Drug …, 2002 - nature.com
C Zuany-Amorim, J Hastewell, C Walker
Nature Reviews Drug Discovery, 2002nature.com
The family of Toll-like receptors (TLRs) is receiving considerable attention as potential
regulators and controllers of the immune response through their ability to recognize
pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as
microbial components, are recognized by TLRs, and that small-molecular-mass synthetic
compounds activate TLRs, raised interest in these receptors as potential targets for the
development of new therapies for multiple diseases. In this review, we discuss the current …
Abstract
The family of Toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through their ability to recognize pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as microbial components, are recognized by TLRs, and that small-molecular-mass synthetic compounds activate TLRs, raised interest in these receptors as potential targets for the development of new therapies for multiple diseases. In this review, we discuss the current and future use of TLR agonists or antagonists in chronic inflammatory diseases and highlight potential problems that are associated with such approaches.
nature.com