Vitamin E attenuates induction of elastase-like activity by tumor necrosis factor-α, cholestan-3β, 5α, 6β-triol and linoleic acid in cultured endothelial cells

M Toborek, B Hennig - Clinica chimica acta, 1993 - Elsevier
Disturbances in arterial wall elastin metabolism appear to be important factors in
atherosclerosis development. To evaluate this hypothesis, elastase-like activity was
determined in cultured endothelial cells and their surrounding media after exposure to tumor
necrosis factor-α (TNF), cholestan-3β, 5α, 6β-triol (Triol) and linoleic acid (18: 2). Significant
increases in elastase-like activity both in the cells and in the media were observed when
subconfluent endothelial cells were treated with 12 μM Triol, 500 U TNF/ml, or 90 μM 18: 2 …

[CITATION][C] Vitamin E attenuates induction of elastase-like activity by tumor necrosis factor- , cholestan-3 , 5 , 6 -triol and linoleic acid in cultured endothelial cells

M Toborek, B Hennig - Clinica Chimica Acta, 1993 - Elsevier